Essentials: Food & Supplements for Brain Health & Cognitive Performance

Essentials: Food & Supplements for Brain Health & Cognitive Performance

September 11, 2025 β€’ 36 min
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πŸ€– AI Summary

Overview

This episode explores the relationship between food, nutrients, and brain health, focusing on actionable strategies to enhance cognitive performance and long-term brain function. It delves into the science of essential nutrients, the mechanisms behind food preferences, and practical tools to rewire dietary habits for better health.

Notable Quotes

- What you are seeking when you eat is not taste, not dopamine, not even a rise in blood glucose. You are seeking things that allow your neurons to be metabolically active. – Andrew Huberman, on the subconscious drivers of food choices.

- Even within seven to 14 days, you can rewire your brain to find healthier foods more rewarding. – Andrew Huberman, on reshaping food preferences.

- Your belief about what a food contains can directly impact your physiological response to it. – Andrew Huberman, on the power of belief in food consumption.

🧠 Brain-Supporting Nutrients

- Omega-3 Fatty Acids (EPA/DHA):

- Critical for maintaining the structural integrity of neurons.

- Found in fish, walnuts, chia seeds, and soybeans. Supplementation of 1.5–3 grams/day is recommended for cognitive benefits.

- Phosphatidylserine:

- Supports neuronal function and is abundant in fish and meat. Supplements are an alternative for non-meat eaters.

- Choline:

- Essential for acetylcholine production, which enhances focus and memory.

- Best sources include egg yolks, potatoes, nuts, and seeds. Aim for 500–1,000 mg/day.

- Creatine:

- Fuels brain circuits involved in mood and motivation.

- Found in meat or supplemented as creatine monohydrate (5 grams/day).

- Anthocyanins:

- Found in blueberries, blackberries, and dark currants. These compounds reduce inflammation and improve brain function.

🍴 The Science of Food Preferences

- Food preferences are shaped by three mechanisms:

- Taste: Sensors on the tongue detect sweet, salty, sour, bitter, and umami flavors.

- Gut-Brain Signaling: Neurons in the gut (neuropod cells) sense nutrient content and trigger dopamine release, reinforcing food choices.

- Learned Associations: Pairing flavors with metabolic benefits can condition preferences over time.

- Practical Tip: Pair less palatable but healthy foods with enjoyable ones to condition a preference for the healthier option.

πŸ”„ Rewiring Food Preferences

- Belief Effects:

- Studies show that what you believe about a food (e.g., its calorie content) can alter physiological responses like insulin release.

- Leverage this by consciously associating healthy foods with positive outcomes.

- Artificial Sweeteners:

- Avoid pairing them with high-glucose foods to prevent disruptions in blood sugar regulation.

- Consume them separately to minimize metabolic confusion.

- Timeline for Change:

- Consistently consuming healthier foods for 7–14 days can shift taste preferences and increase their perceived reward value.

🍬 Dopamine, Sweetness, and Food Addiction

- Sweet foods activate the dopamine system, reinforcing their consumption.

- Overexposure to highly palatable foods (e.g., sugary or processed items) can skew the brain’s reward system, making healthier options less appealing.

- Gradual reduction of super-sweet foods can recalibrate the dopamine system to appreciate less sugary, nutrient-dense options.

πŸ›  Tools for Better Eating Habits

- Focus on Nutrient Density: Prioritize foods rich in omega-3s, choline, and anthocyanins for brain health.

- Leverage Belief Effects: Cultivate positive associations with healthy foods to enhance their appeal.

- Mindful Pairing: Pair healthy but less desirable foods with enjoyable ones to condition preferences.

- Avoid Sweetener-Food Pairing: Separate artificial sweeteners from high-glucose meals to maintain proper blood sugar regulation.

- Consistency is Key: Regularly consuming brain-healthy foods can rewire preferences within two weeks.

AI-generated content may not be accurate or complete and should not be relied upon as a sole source of truth.

πŸ“‹ Episode Description

In this Huberman Lab Essentials episode, I discuss science-supported nutrients that directly support brain structure, function and long-term cognitive health.


I highlight specific nutrients, including omega-3 fatty acids, creatine, phosphatidylserine, anthocyanins, choline and glutamine, and discuss their recommended doses and dietary sources. I also describe how taste perception, gut-brain signaling and learned associations shape what foods we prefer and crave. Finally, I share practical behavioral tools to help rewire your food preferences toward healthier choices.


Read the episode show notes at hubermanlab.com.


Thank you to our sponsors


AGZ by AG1: https://drinkagz.com/huberman


David: https://davidprotein.com/huberman


LMNT: https://drinklmnt.com/huberman


Timestamps


00:00:00 Food & Brain Health


00:01:32 Structural Fat & Neurons, Tools: Omega-3s, EPA; Phosphatidylserine


00:05:11 Acetylcholine & Focus, Tool: Dietary Choline


00:06:48 Creatine & Brain Health, Tool: Creatine Supplementation


00:08:26 Sponsor: David


00:09:41 Anthocyanins & Brain Function, Tool: Blueberries & Berries


00:10:52 Glutamine & Brain, Tool: Glutamine & Offset Sugar Cravings


00:12:48 Brain-Boosting Nutrients, Foods & Supplements


00:15:03 Food Preference; Yum, Yuck or Meh; Mouth, Taste & Palatability


00:19:30 Gut, Nutrients & Subconscious Signaling


00:21:56 Learned Food Preferences


00:23:36 Sponsors: AGZ by AG1 & LMNT


00:26:16 Food & Learned Associations, Tool: Unpair Artificial Sweeteners


00:30:18 Belief Effects, Satiety, Tool: Rewiring Food Preferences


00:35:48 Recap & Key Takeaways


Disclaimer & Disclosures

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