Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman

Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman

November 13, 2025 49 min
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🤖 AI Summary

Overview

This episode features Dr. Jack Feldman, a leading expert in the science of breathing, discussing the mechanics of respiration, its neural regulation, and its profound impact on mental and physical health. The conversation explores the role of breathing in emotional regulation, cognitive function, and overall performance, while offering practical tools like breathwork techniques and magnesium L-threonate supplementation.

Notable Quotes

- Without a diaphragm, you're an amphibian. - Dr. Jack Feldman, on the evolutionary importance of the diaphragm in enabling larger brain development.

- We sigh about every 5 minutes. And you can't stop it—it just happens. - Dr. Jack Feldman, on the automatic mechanism of physiological sighs to maintain lung health.

- My mice don't believe in the placebo effect. - Dr. Jack Feldman, on the value of rodent studies in understanding the mechanisms of breathwork and its impact on emotional states.

🫁 The Mechanics of Breathing

- Breathing is essential for oxygen intake and carbon dioxide removal, which regulates blood pH and supports cellular function.

- The diaphragm is the primary muscle for inhalation, contracting to expand the lungs and create negative pressure that draws air in.

- The pre-Bötzinger complex in the brainstem generates the rhythm of breathing, activating motor neurons that control the diaphragm and intercostal muscles.

🌬️ The Science of Breathing Patterns

- Nasal breathing is preferred at rest due to its efficiency, while mouth breathing is used during exercise to increase airflow.

- Physiological sighs, occurring every 5 minutes, prevent alveoli collapse and maintain lung health by reopening tiny air sacs.

- Active expiration, such as during exercise or stress, involves a secondary brain oscillator near the facial nucleus, which activates expiratory muscles.

🧠 Breathing and Emotional Regulation

- Slow breathing practices can reduce fear and anxiety by modulating brain activity, as demonstrated in rodent studies.

- Breathing influences brain states through mechanisms like olfactory signals, vagus nerve activity, and carbon dioxide regulation.

- Hyperventilation can lower CO2 levels, leading to anxiety, while controlled breathing can restore balance and alleviate symptoms.

🌀 Breathwork Practices for Mental and Physical Health

- Techniques like box breathing (e.g., 5 seconds inhale, 5 seconds hold, 5 seconds exhale, 5 seconds hold) can improve focus and reduce stress.

- Dr. Feldman recommends starting with 5-10 minutes of simple breathwork daily, emphasizing accessibility for beginners.

- Practices like Wim Hof and Tummo breathing are also discussed as effective methods for enhancing mental and physical performance.

💊 Magnesium L-Threonate for Cognitive Health

- Magnesium L-threonate enhances cognitive function by increasing magnesium levels in the brain, which boosts neuroplasticity and memory.

- A clinical trial showed that participants with mild cognitive decline improved their cognitive age by an average of 8 years after three months of supplementation.

- Dr. Feldman personally uses magnesium L-threonate to maintain cognitive health and recommends it for improving sleep and slowing cognitive decline.

AI-generated content may not be accurate or complete and should not be relied upon as a sole source of truth.

📋 Episode Description

In this Huberman Lab Essentials episode, my guest is Dr. Jack Feldman, PhD, a Distinguished Professor of Neurobiology at the University of California, Los Angeles, and a leading expert in the science of breathing.


We explain the mechanics of breathing and the neural circuits that generate and regulate our breathing rhythm. We also discuss how breathing patterns profoundly influence mental states, including their role in reducing anxiety and enhancing emotional resilience. Dr. Feldman also shares practical tools, such as box breathing for daily performance and magnesium L-threonate supplementation to support cognitive health and longevity.


Read the episode show notes at hubermanlab.com.


Thank you to our sponsors


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Timestamps


00:00:00 Jack Feldman


00:00:23 Breathing Mechanics, Diaphragm; Pre-Bötzinger Complex & Breath Initiation


00:03:25 Nose vs Mouth Breathing


00:04:23 Sponsor: Mateina


00:05:24 Active Expiration & Brain; Retrotrapezoid Nucleus


00:08:32 Diaphragm & Evolution; Lung Surface Area & Alveoli, Oxygen Exchange


00:12:56 Diaphragmatic vs Non-Diaphragmatic Breathing


00:14:23 Physiological Sighs: Frequency & Function; Polio & Ventilators


00:18:21 Sponsor: AGZ by AG1


00:19:52 Drug Overdose, Death & Gasps


00:21:38 Meditation, Slow Breathing & Fear Conditioning Study


00:25:28 Mechanistic Science in Breathwork Validation; Breath Practice & Reduced Fear


00:27:21 Breathing & Emotional/Cognitive State, Olfaction, Vagus Nerve


00:29:44 Carbon Dioxide, Hyperventilation & Anxiety


00:31:21 Sponsor: Eight Sleep


00:32:47 Breathing, Emotion & Autonomic Processes Coordination; Depression & Breath Practices


00:36:43 Tool: Breathwork Practices, Box Breathing, Tummo, Wim Hof


00:38:46 Magnesium L-Threonate & Cognitive Enhancement; Compound Refinement


00:44:28 Clinical Trial, Magnesium L-Threonate & Cognitive Improvements; Dose, Sleep


00:48:28 Acknowledgements


Disclaimer & Disclosures

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