Essentials: Understanding & Treating Addiction | Dr. Anna Lembke

Essentials: Understanding & Treating Addiction | Dr. Anna Lembke

June 26, 2025 36 min
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🤖 AI Summary

Overview

This episode explores the neuroscience of addiction, focusing on dopamine's role in reward, motivation, and the pleasure-pain balance. Dr. Anna Lembke discusses how modern life contributes to addiction, strategies for recovery, and the potential of psychedelic-assisted therapy. The conversation also delves into the addictive nature of social media and the importance of truth-telling in recovery.

Notable Quotes

- Life is not necessarily boring because there's something wrong with our brains, but because our brains are not suited to this world.Dr. Anna Lembke, on modern life's role in addiction.

- Pleasure and pain are co-located in the brain, and the balance always seeks to return to neutral. Overindulgence tips it toward pain.Dr. Anna Lembke, explaining the pleasure-pain balance.

- Telling the truth strengthens the brain's prefrontal circuits, reconnecting them to the reward system and aiding recovery.Dr. Anna Lembke, on the neuroscience of honesty in addiction recovery.

🧠 Dopamine: The Driver of Reward and Addiction

- Dopamine is a neurotransmitter central to reward, motivation, and movement. It operates on a baseline level, with deviations above or below this baseline creating pleasure or pain.

- Chronic overexposure to high-dopamine activities (e.g., drugs, social media) lowers the baseline, leading to a dopamine deficit state akin to depression.

- Genetics and early life experiences influence baseline dopamine levels, but environmental factors and behaviors can significantly alter them over time.

⚖️ The Pleasure-Pain Balance and Addiction

- The brain's pleasure and pain systems are interconnected, functioning like a seesaw. Overindulgence in pleasurable activities leads to a compensatory tilt toward pain.

- This mechanism explains the come down after pleasurable experiences and the drive to repeat behaviors, often leading to addiction.

- Recovery requires rebalancing the system, often through abstinence. A 30-day dopamine fast can reset the brain's reward pathways, though the first two weeks are typically the hardest.

🌍 Modern Life, Boredom, and Addiction

- Modern conveniences eliminate the need for survival-driven challenges, leaving many people feeling unfulfilled.

- Individuals with higher needs for friction or stimulation are particularly vulnerable to addiction.

- Addiction often stems from a mismatch between the brain's evolutionary design and the overstimulating, low-effort environment of modern life.

💊 Psychedelic-Assisted Therapy: Promise and Pitfalls

- Psychedelics like psilocybin and MDMA show promise in treating addiction and trauma when used in controlled, therapeutic settings.

- These substances may provide a transformative perspective shift, helping individuals reconnect with values and relationships.

- However, Dr. Lembke warns against unsupervised use, emphasizing that addiction is a chronic condition unlikely to be resolved by a single experience.

📱 Social Media as a Digital Drug

- Social media is engineered to be addictive, exploiting the dopamine system.

- Healthy use requires intentional planning and boundaries to prevent overuse and maintain focus on real-life connections.

- Excessive social media use disrupts sustained thought processes, diminishing creativity and original thinking.

AI-generated content may not be accurate or complete and should not be relied upon as a sole source of truth.

📋 Episode Description

In this Huberman Lab Essentials episode, my guest is Dr. Anna Lembke, MD, Chief of the Stanford Addiction Medicine Dual Diagnosis Clinic at Stanford University School of Medicine.


We discuss how dopamine drives reward, motivation and addictive behaviors. Dr. Lembke explains the concept of the pleasure-pain balance of dopamine and how this cycle plays a key role in the development and persistence of addiction. We also discuss some of the challenges of addiction recovery, including withdrawal, relapses and the potential benefits of psychedelic-assisted therapy.


Read the episode show notes at hubermanlab.com.


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Timestamps


00:00:00 Anna Lembke


00:00:15 Dopamine, Reward & Movement


00:01:54 Baseline Dopamine; Genetics, Temperament & Addiction


00:05:24 Addiction, Modern Life & Boredom


00:07:18 Sponsor: AG1


00:08:55 Pleasure-Pain Balance, Dopamine, Addiction


00:14:17 Resetting Dopamine, Substance or Behavior Recovery, Tool: 30-Day Abstinence


00:16:04 Relapse, Addiction, Reflexive Behavior, Empathy


00:20:17 Triggers, Relapse, Dopamine


00:23:15 Sponsor: Wealthfront & BetterHelp


00:26:04 Shame, Truth Telling & Recovery


00:28:26 Addiction, Psychedelic-Assisted Therapy, Psilocybin, MDMA


00:33:29 Social Media & Addiction, Tool: In