Essentials: The Science of Gratitude & How to Build a Gratitude Practice

Essentials: The Science of Gratitude & How to Build a Gratitude Practice

October 23, 2025 39 min
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🤖 AI Summary

Overview

This episode explores the science behind gratitude and its profound effects on mental and physical health. It challenges conventional gratitude practices, emphasizing the importance of receiving gratitude and engaging with powerful narratives to activate specific brain circuits. Practical tools for building an effective gratitude practice are shared, alongside insights into its benefits for reducing anxiety, enhancing motivation, and improving immune function.

Notable Quotes

- Gratitude is one of the most potent wedges by which we can insert our thinking and physiology between defensive and pro-social neural circuits. - Andrew Huberman, on the transformative power of gratitude.

- To really activate these circuits for gratitude, one has to powerfully associate with the idea of receiving help. - Andrew Huberman, on the importance of receiving gratitude over giving it.

- Genuine thanks are what count. You can't fake gratitude—your brain knows. - Andrew Huberman, on the necessity of authenticity in gratitude practices.

🧠 The Science of Gratitude

- Gratitude activates pro-social neural circuits, which enhance connection and reduce defensive behaviors.

- Serotonin plays a key role, increasing activity in brain areas like the anterior cingulate cortex and medial prefrontal cortex, which are linked to positive emotions and motivation.

- Gratitude shifts the brain's seesaw between pro-social and defensive circuits, creating long-lasting changes in mindset and physiology.

📖 Story-Based Gratitude Practices

- Effective gratitude practices involve receiving gratitude or observing genuine acts of gratitude in others, embedded within compelling narratives.

- Stories of survival or impactful human connection activate gratitude-related brain circuits more robustly than listing things you're grateful for.

- Repeated engagement with a meaningful story enhances emotional and physiological benefits, including heart rate and breathing regulation.

💡 Practical Tools for Gratitude

- Identify a powerful narrative of gratitude—either your own experience of receiving thanks or observing someone else’s genuine gratitude exchange.

- Write down bullet points summarizing the story to revisit it regularly.

- Spend 1-5 minutes reflecting deeply on the emotional weight of the story to activate gratitude circuits effectively.

🩺 Gratitude’s Impact on Health

- Regular gratitude practices reduce activity in the amygdala, the brain’s fear center, and lower levels of inflammatory markers like TNF-alpha and IL-6.

- Gratitude enhances motivation and diminishes anxiety by altering brain-heart connectivity and emotion-related neural pathways.

- These changes occur rapidly, with measurable benefits for mental and physical health after even brief gratitude practices.

AI-generated content may not be accurate or complete and should not be relied upon as a sole source of truth.

📋 Episode Description

In this Huberman Lab Essentials episode, I explore the science of gratitude and how to develop an effective, research-supported gratitude practice.


I explain why common gratitude practices (like simply listing things you're grateful for) are far less impactful than engaging in story-based gratitude practices. I also explain how being grateful activates specific brain regions, which enhance calm, social connection and motivation, while reducing anxiety and inflammation. Finally, I share why we can't simply trick our brains into feeling grateful and describe a practical weekly gratitude practice that will improve both your mental and physical well-being.


Read the episode show notes at hubermanlab.com.


Thank you to our sponsors


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Timestamps


(0:00) Gratitude


(0:30) Gratitude Practice Benefits


(3:22) Pro-Social vs Defensive Behaviors, Gratitude


(6:25) Sponsor: Eight Sleep


(8:07) Serotonin, Brain & Context, Gratitude Mindset


(14:02) Context, Can You Lie to Yourself?


(14:48) Effective Gratitude Practice, Tools: Receiving Gratitude, Story


(21:18) Sponsor: AGZ by AG1


(22:47) Tool: Find & Revisit Inspirational Stories


(27:30) Heartfelt Intention, Genuine Thanks


(29:42) Sponsor: Our Place


(31:03) Gratitude Practice Benefits for Anxiety, Fear & Motivation


(33:29) Gratitude Practice Benefits for Immune System


(36:02) Recap: Establishing an Effective Gratitude Practice


Disclaimer & Disclosures

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